High temperatures and severe drought contributed to extensive tree mortality from fires and bark beetles during the 2000s in parts of the western continental United States. Several states in this region have greenhouse gas (GHG) emission targets and would benefit from information on the amount of carbon stored in tree biomass killed by disturbance. We quantified mean annual tree mortality from fires, bark beetles, and timber harvest from 2003–2012 for each state in this region. We estimated tree mortality from fires and beetles using tree aboveground carbon (AGC) stock and disturbance data sets derived largely from remote sensing. We quantified tree mortality from harvest using data from US Forest Service reports. In both cases, we used Monte Carlo analyses to track uncertainty associated with parameter error and temporal variability. Regional tree mortality from harvest, beetles, and fires (MORTH+B+F) together averaged 45.8 ± 16.0 Tg AGC yr−1 (±95% confidence interval), indicating a mortality rate of 1.10 ± 0.38% yr−1. Harvest accounted for the largest percentage of MORTH+B+F (~50%), followed by beetles (~32%), and fires (~18%). Tree mortality from harvest was concentrated in Washington and Oregon, where harvest accounted for ~80% of MORTH+B+F in each state. Tree mortality from beetles occurred widely at low levels across the region, yet beetles had pronounced impacts in Colorado and Montana, where they accounted for ~80% of MORTH+B+F. Tree mortality from fires was highest in California, though fires accounted for the largest percentage of MORTH+B+F in Arizona and New Mexico (~50%). Drought and human activities shaped regional variation in tree mortality, highlighting opportunities and challenges to managing GHG emissions from forests. Rising temperatures and greater risk of drought will likely increase tree mortality from fires and bark beetles during coming decades in this region. Thus, sustained monitoring and mapping of tree mortality is necessary to inform forest and GHG management.